Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice.
Department of Family and Community Medicine, University of Arizona, Tucson 85624.
- Published Article
- Publication Date
Nov 01, 1993
Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and gamma-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/7513605