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Reduction of tumor necrosis factor production by splenocytes from v-Ha-ras oncogene-bearing mice.

Authors
  • Chen, G J1
  • Colombo, L L
  • Lopez, M C
  • Watson, R R
  • 1 Department of Family and Community Medicine, University of Arizona, Tucson 85624.
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Nov 01, 1993
Volume
74
Issue
3
Pages
147–150
Identifiers
PMID: 7513605
Source
Medline
Language
English
License
Unknown

Abstract

Mice containing the activated v-Ha-ras oncogene driven by the mouse mammary tumor virus promoter/enhancer produced less tumor necrosis factor (TNF) than genetically identical animals without it. Inbred Oncomice containing the v-Ha-ras oncogene and inbred FVB mice without it were grown for 6 months. Splenocytes were isolated and stimulated in vitro to produce tumor necrosis factor (TNF) and gamma-interferon (IFN). TNF production by cells from Oncomice was significantly decreased compared to cells from FBV mice. There was a tendency for decrease, but no significant difference was seen on IFN release. These observations suggest that the oncogene may play a role in the immune system.

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