Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trials

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Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trials

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BioMed Central
Publication Date
Jan 01, 2006
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PMC
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Abstract

cc5084.fm Available online http://ccforum.com/content/10/6/R153 Open AccessVol 10 No 6Research Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trials Mette M Berger1, Philippe Eggimann1, Daren K Heyland2, René L Chioléro1, Jean-Pierre Revelly1, Andrew Day2, Wassim Raffoul3 and Alan Shenkin4 1Department of Adult Intensive Care Medicine & Burn Centre, Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon 46, 1011 Lausanne, Switzerland 2Clinical Evaluation Research Unit, Kingston General Hospital, 76 Stuart Street, K7L 2V7 Kingston, Ontario, Canada 3Plastic and Reconstructive Surgery, Department of Surgery, CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland 4Department of Clinical Chemistry, University of Liverpool, Duncan Building, Daulby Street, L69 3GA Liverpool, UK Corresponding author: Mette M Berger, [email protected] Received: 16 Aug 2006 Revisions requested: 12 Sep 2006 Revisions received: 22 Sep 2006 Accepted: 2 Nov 2006 Published: 2 Nov 2006 Critical Care 2006, 10:R153 (doi:10.1186/cc5084) This article is online at: http://ccforum.com/content/10/6/R153 © 2006 Berger et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Nosocomial pneumonia is a major source of morbidity and mortality after severe burns. Burned patients suffer trace element deficiencies and depressed antioxidant and immune defences. This study aimed at determining the effect of trace element supplementation on nosocomial or intensive care unit (ICU)-acquired pneumonia. Methods Two consecutive, randomised, double-blinded, supplementation studies including two homogeneous groups of 41 severely burned patients (20 placebo and 21 intervention) admitte

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