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Reduction of absorption of paracetamol by activated charcoal and cholestyramine: a possible therapeutic measure.

Authors
  • Dordoni, B
  • Willson, R A
  • Thompson, R P
  • Williams, R
Type
Published Article
Journal
BMJ
Publisher
BMJ
Publication Date
Jul 14, 1973
Volume
3
Issue
5871
Pages
86–87
Identifiers
PMID: 4717848
Source
Medline
License
Unknown

Abstract

The absorption of an oral 2-g dose of paracetamol was markedly reduced by the simultaneous oral administration of either activated charcoal or cholestyramine but was only slightly reduced when the adsorbents were given 60 minutes after the paracetamol. Since the absorption of a larger dose of the drug will probably be slow, the administration of adsorbents may be of value even when delayed several hours.

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