Affordable Access

Reduced responsiveness of locus coeruleus neurons to cutaneous thermal stimuli in capsaicin-treated rats.

Authors
  • Hajós, M
  • Engberg, G
  • Elam, M
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Oct 20, 1986
Volume
70
Issue
3
Pages
382–387
Identifiers
PMID: 3022199
Source
Medline
License
Unknown

Abstract

Recent electrophysiological experiments have shown that brain norepinephrine (NE) neurons in the locus coeruleus (LC) are activated by cutaneous thermal stimuli of both non-noxious and noxious character. In the present study the LC neuronal response to thermal stimuli was used to evaluate cutaneous thermal sensitivity in capsaicin-treated rats, a treatment that is described to cause impaired thermoregulation. Capsaicin treatment, of neonates as well as of adult rats, caused a reduced responsiveness of brain LC neurons to thermal stimuli. The results suggest that a reduction in peripheral thermal afferent transmission may be one mechanism underlying the capsaicin-induced thermoregulatory dysfunction.

Report this publication

Statistics

Seen <100 times