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Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera

Authors
  • Supasa, Piyada1
  • Zhou, Daming2
  • Dejnirattisai, Wanwisa1
  • Liu, Chang1, 3
  • Mentzer, Alexander J.1, 4
  • Ginn, Helen M.5
  • Zhao, Yuguang2
  • Duyvesteyn, Helen M.E.2
  • Nutalai, Rungtiwa1
  • Tuekprakhon, Aekkachai1
  • Wang, Beibei1
  • Paesen, Guido C.2
  • Slon-Campos, Jose1
  • López-Camacho, César1
  • Hallis, Bassam6
  • Coombes, Naomi6
  • Bewley, Kevin6
  • Charlton, Sue6
  • Walter, Thomas S.2
  • Barnes, Eleanor4, 7, 8, 9
  • And 33 more
  • 1 Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
  • 2 Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The, Wellcome Centre for Human Genetics, Oxford, UK
  • 3 Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK
  • 4 Oxford University Hospitals NHS Foundation Trust, Oxford, UK
  • 5 Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK
  • 6 National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK
  • 7 Peter Medawar Building for Pathogen Research, Oxford, UK
  • 8 NIHR Oxford Biomedical Research Centre, Oxford, UK
  • 9 Translational Gastroenterology Unit, University of Oxford, Oxford, UK
  • 10 Centre For Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK
  • 11 Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand
  • 12 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
  • 13 Nuffield Department of Medicine, University of Oxford, Oxford, UK
  • 14 Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK
  • 15 Worthing Hospital, Worthing, UK
  • 16 MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
  • 17 Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK
  • 18 Sir William Dunn School of Pathology University of Oxford, Oxford, UK
  • 19 Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
  • 20 Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford, UK
Type
Published Article
Journal
Cell
Publisher
The Authors. Published by Elsevier Inc.
Publication Date
Feb 18, 2021
Identifiers
DOI: 10.1016/j.cell.2021.02.033
PMCID: PMC7891044
Source
PubMed Central
License
Unknown

Abstract

The SARS-CoV-2 B.1.1.7 variant is not neutralized as easily as the original form of the virus. Some public antibodies cannot neutralize B.1.1.7, due to altered light chain contacts with residue 501. However, B.1.1.7 does not show widespread escape from monoclonal antibodies, natural antibody responses, or vaccines.

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