Affordable Access

deepdyve-link
Publisher Website

Reduced-intensity hematopoietic stem cell transplants for malignancies: harnessing the graft-versus-tumor effect.

Authors
  • Gill, Saar
  • Porter, David L
Type
Published Article
Journal
Annual Review of Medicine
Publisher
Annual Reviews
Publication Date
Jan 01, 2013
Volume
64
Pages
101–117
Identifiers
DOI: 10.1146/annurev-med-121411-103452
PMID: 23121181
Source
Medline
License
Unknown

Abstract

Allogeneic hematopoietic cell transplantation combines the power of cytotoxic chemo/radiotherapy with the ability of the new immune system to seek out and destroy tumor cells. However, administration of such myeloablative transplants is fraught with risks, some of which are related to the intensive conditioning regimens. Reductions in the intensity of the administered cytotoxic therapy have demonstrated that under some circumstances, the burden of fighting tumor and enhancing stem cell engraftment can be shouldered mostly by the transplanted immune system. Reduced intensity has allowed a potentially curative therapy for hematologic malignancies to be offered to an expanded patient population. Ongoing research seeks to enhance the safety and power of this form of allogeneic immunotherapy.

Report this publication

Statistics

Seen <100 times