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Reduced Hippocampal Activation During Recall is Associated with Elevated FMR1 mRNA and Psychiatric Symptoms in Men with the Fragile X Premutation

Authors
  • Koldewyn, Kami1, 2
  • Hessl, David1, 3
  • Adams, John1
  • Tassone, Flora1, 4
  • Hagerman, Paul J.1, 4
  • Hagerman, Randi J.1, 5
  • Rivera, Susan M.1, 2, 6
  • 1 University of California-Davis, Medical Center, Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute, Sacramento, USA , Sacramento (United States)
  • 2 University of California-Davis, Center for Mind and Brain, 202 Cousteau Place, Davis, CA, 95618, USA , Davis (United States)
  • 3 University of California-Davis, Medical Center, Department of Psychiatry and Behavioral Sciences, Sacramento, USA , Sacramento (United States)
  • 4 University of California-Davis, School of Medicine, Department of Biochemistry and Molecular Medicine, Sacramento, USA , Sacramento (United States)
  • 5 University of California-Davis, Medical Center, Department of Pediatrics, Sacramento, USA , Sacramento (United States)
  • 6 University of California-Davis, Department of Psychology, Davis, CA, USA , Davis (United States)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Jan 18, 2008
Volume
2
Issue
2
Pages
105–116
Identifiers
DOI: 10.1007/s11682-008-9020-9
Source
Springer Nature
Keywords
License
Yellow

Abstract

Recent studies reveal that young carriers of the fragile X premutation are at increased risk for psychiatric conditions, memory problems and executive deficits. Post mortem and structural MRI studies suggest the hippocampus is preferentially affected by the premutation. The current study utilized magnetic resonance imaging (MRI) to explore the relationship between hippocampal structure and function as well as molecular/genetic and psychiatric measures in men with the fragile X premutation. Although the groups did not differ in hippocampal volume, the premutation group showed reduced left hippocampal activation and increased right parietal activation during a recall task relative to controls. These results suggest that brain function underlying memory recall is affected by premutation status. Left hippocampal activation was negatively correlated with both FMR1 mRNA level and psychiatric symptomology in the premutation group. These associations support the theory that increased levels of FMR1 mRNA affect brain function and contribute to psychiatric symptoms.

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