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Redefinition of Affymetrix probe sets by sequence overlap with cDNA microarray probes reduces cross-platform inconsistencies in cancer-associated gene expression measurements.

Authors
  • Carter, Scott L
  • Eklund, Aron C
  • Mecham, Brigham H
  • Kohane, Isaac S
  • Szallasi, Zoltan
Type
Published Article
Journal
BMC Bioinformatics
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2005
Volume
6
Pages
107–107
Identifiers
PMID: 15850491
Source
Medline
License
Unknown

Abstract

We have shown that probes which target overlapping transcript sequence regions on cDNA microarrays and Affymetrix gene-chips exhibit a greater level of concordance than the corresponding Unigene or sequence matched features. This method will be useful for the integrated analysis of gene expression data generated by multiple disparate measurement platforms.

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