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Recurrent Lupus nephritis in the Second Allograft of a Patient with Systemic Lupus erythematosus

Authors
  • Isaac, Jorge
  • Shihab, Fuad S.
Type
Published Article
Journal
Nephron
Publisher
S. Karger AG
Publication Date
Oct 18, 2002
Volume
92
Issue
4
Pages
947–949
Identifiers
DOI: 10.1159/000065458
PMID: 12399648
Source
Karger
Keywords
License
Green
External links

Abstract

Lupus glomerulonephritis is a common and serious complication of systemic lupus erythematosus (SLE) affecting up to 50% of lupus patients. Recurrent lupus nephritis is rare, complicating as low as 1% of the lupus transplant population according to some authors. However, it may be underreported with more realistic recurrent rates oscillating from 2.8 to 8.7%. We report the case of a patient with SLE who lost her first allograft 4 years after transplantation with a diagnosis of de novo fibrillary glomerulopathy. She underwent a second renal transplantation and her renal function was stable for the past 5 years. She now presented with skin rash, arthralgias and positive lupus serologies. Her creatinine was slightly elevated and proteinuria was also noted. A renal biopsy performed revealed a recurrent focal proliferative lupus nephritis (WHO III). Retrospectively, we believe that her first allograft was also lost to recurrent lupus nephritis. This is a unique case of recurrent lupus nephritis in the second allograft of a patient with SLE.

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