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Recurrence of hemolytic uremic syndrome after live related renal transplantation associated with subsequent de novo disease in the donor

Authors
  • Donne, Rosemary L.
  • Abbs, Ian
  • Barany, Peter
  • Elinder, Carl-Gustaf
  • Little, Mark
  • Conlon, Peter
  • Goodship, Timothy H.J.
Type
Published Article
Journal
American Journal of Kidney Diseases
Publication Date
Jan 01, 2002
Accepted Date
Aug 21, 2002
Volume
40
Issue
6
Pages
1–4
Identifiers
DOI: 10.1053/ajkd.2002.36938
Source
Elsevier
Keywords
License
Unknown

Abstract

There is a significant risk of disease recurrence in patients with nondiarrheal (D−) hemolytic uremic syndrome (HUS) undergoing renal transplantation. Recent studies have found that approximately 20% of sporadic cases of HUS have mutations in the gene for the complement regulatory protein factor H. The authors report on 2 families, in each of which a family member initially presented with sporadic HUS and subsequently received a live-related renal transplant, one from a sibling and the other from the father. Subsequently, both recipients suffered recurrent HUS in the allograft, and both donors had HUS within a year of the transplant. Neither family has a factor H mutation. This report underlines the risk of disease recurrence in recipients associated with live-related renal transplantation in HUS and also suggests that the donors may be at risk. Am J Kidney Dis 40:E22. © 2002 by the National Kidney Foundation, Inc.

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