Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Recruitment of polycomb group complexes and their role in the dynamic regulation of cell fate choice.

Authors
  • Schuettengruber, Bernd
  • Cavalli, Giacomo
Type
Published Article
Journal
Development
Publisher
The Company of Biologists
Publication Date
Nov 01, 2009
Volume
136
Issue
21
Pages
3531–3542
Identifiers
DOI: 10.1242/dev.033902
PMID: 19820181
Source
Medline
License
Unknown

Abstract

Polycomb group (PcG) protein complexes dynamically define cellular identity through the regulation of key developmental genes. Important advances in the PcG field have come from genome-wide mapping studies in a variety of tissues and cell types that have analyzed PcG protein complexes, their associated histone marks and putative mechanisms of PcG protein recruitment. We review how these analyses have contributed to our understanding of PcG protein complex targeting to chromatin and consider the importance of diverse PcG protein complex composition for gene regulation. Finally, we focus on the dynamics of PcG protein complex action during cell fate transitions and on the implications of histone modifications for cell lineage commitment.

Report this publication

Statistics

Seen <100 times