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Reconstruction Using Free Vascularized Fibular Grafts after Wide Resection of Humerus Chondrosarcoma in a Patient with Cleidocranial Dysplasia

Authors
  • Shimizu, Junya
  • Iba, Kousuke
  • Emori, Makoto
  • Sasaki, Mikito
  • Yamashita, Toshihiko
Type
Published Article
Journal
Case Reports in Orthopedics
Publisher
Hindawi Limited
Publication Date
Mar 08, 2021
Volume
2021
Identifiers
DOI: 10.1155/2021/2302879
PMID: 33747589
PMCID: PMC7960051
Source
PubMed Central
Disciplines
  • Case Report
License
Unknown

Abstract

Cleidocranial dysplasia is characterized by hypoplasia of the clavicles, unerupted teeth, narrow pelvis, short stature, and craniofacial malformations. A cause of this skeletal dysplasia is heterozygous mutations of the runt-related transcription factor 2 gene ( Runx2 ), a master regulator for bone and cartilage development. Chondrosarcoma is a primary malignant bone tumor that is usually treated by wide resection surgery. This report shows a case of a 25-year-old female patient with cleidocranial dysplasia who was affected with chondrosarcoma of the left humerus. We performed wide resection of the tumor and reconstruction of the large bone defect of the humerus using free vascularized fibular grafts. The patient preserved the hand function and activity of daily life as the same level as preoperative condition more than five years after the surgery.

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