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Reconstitution of ionic channels from human heart.

Authors
  • Hill, J A Jr
  • Coronado, R
  • Strauss, H C
Type
Published Article
Journal
Journal of molecular and cellular cardiology
Publication Date
Mar 01, 1989
Volume
21
Issue
3
Pages
315–322
Identifiers
PMID: 2473212
Source
Medline
License
Unknown

Abstract

This report is the first description of single ion channels from human myocardium. Using explanted human left ventricular tissue, we have studied three K-conducting and two anion-conducting channels. We report our observations of gating and ionic selectivity properties of these channels which, we argue, derive from both sarcolemmal and sarcoplasmic reticulum membranes. We postulate that one channel is the K-conducting channel (SR K channel) from human cardiac sarcoplasmic reticulum. Another channel is similar to a dimeric Cl- channel from Torpedo electroplax, displaying two equally spaced levels of open state conductance.

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