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[Reconstitution of cyclophosphamide-induced, impaired function of the immune system in animal models].

Authors
  • Artym, Jolanta
Type
Published Article
Journal
Postȩpy higieny i medycyny doświadczalnej
Publication Date
Jan 01, 2003
Volume
57
Issue
1
Pages
55–66
Identifiers
PMID: 12765123
Source
Medline
License
Unknown

Abstract

Cyclophosphamide (CY) is an alkylating agent used in chemotherapy of tumors and autoimmune disorders. The drug causes a large number of side-effects including deep, transient lymphopenia and neutropenia, thus rendering the immune system susceptible to infections. In this review we focus on the effects of CY on the haematopoetic system and the immune response in rodents. In addition, we present approaches aimed at reconstitution of lympho- and myelopoiesis using a spectrum of immunotropic factors including: thymic hormones, cytokines, low-molecular weight compounds, bacterial products and lactoferrin.

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