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Recombinant human tissue factor pathway inhibitor prevents thrombosis in a venous tuck model.

Authors
  • Ezzat, Waleed H
  • Dahl, John P
  • Luginbuhl, Adam
  • Gordin, Eli
  • Krein, Howard
  • Heffelfinger, Ryan N
Type
Published Article
Journal
The Laryngoscope
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 01, 2010
Volume
120
Issue
11
Pages
2172–2176
Identifiers
DOI: 10.1002/lary.20898
PMID: 20939073
Source
Medline
License
Unknown

Abstract

Our data suggests that the use of topical rhTPFI increases venous anastomotic patency rates in vivo. The topical means of administration is attractive, as there seems to be a low percentage of systemic complications as is often seen with anticoagulation therapies. Future studies will investigate the potential efficacy in patients undergoing microvascular free tissue transfer.

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