rh-endostatin was safely administered both by continuous infusion and by twice daily subcutaneous injections up to 120 mg/m(2)/day. Predictable pK was seen in this dose range and the target endostatin levels were reached from 60 mg/m(2)/day and above.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/16012180