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[Recombinant growth hormone increasus callus maturation time in distraction osteogenesis--a histomorphometric study].

Authors
  • Bail, H
  • Raschke, M J
  • Kolbeck, S F
  • Weiler, A
  • Haahr, P M
  • Haas, N P
Type
Published Article
Journal
Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress
Publication Date
Jan 01, 1998
Volume
115
Issue
Suppl I
Pages
675–680
Identifiers
PMID: 14518340
Source
Medline
License
Unknown

Abstract

Purpose of the present study was, to proof whether homologous recombinant GH has an stimulating effect on bone healing in distraction osteogenesis. Therefore the left tibiae of 20 micropigs were osteotomized and distracted over an external fixator 2 mm daily on each of ten consecutive days. Animals were sacrificed after a healing time of another ten days. The treatment group received 100 micrograms r-pGH per kg bodyweight per day. After sacrifice, the regenerates were embedded undecalcified and cut into 6 microns thick sagittal oriented slices. Callus area, bone area, cartilagee area and bone perimeter in the regenerates were measured using an image analysis system. The results revealed, that GH promotes bone formation and maturation of the regenerate without disturbing the callus structure.

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