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Recent progress in nanoscale metal-organic frameworks for drug release and cancer therapy

Authors
  • He, Liangcan1, 2
  • Liu, Yuan2
  • Lau, Joseph2
  • Fan, Wenpei2
  • Li, Qunying1
  • Zhang, Chao1
  • Huang, Pintong1
  • Chen, Xiaoyuan2
  • 1 Department of Ultrasound in Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang 310009, PR China
  • 2 Laboratory of Molecular Imaging & Nanomedicine, National Institute of Biomedical Imaging & Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA
Type
Published Article
Journal
Nanomedicine
Publisher
Future Medicine
Publication Date
Mar 01, 2019
Volume
14
Issue
10
Pages
1343–1365
Identifiers
DOI: 10.2217/nnm-2018-0347
PMID: 31084393
PMCID: PMC6615411
Source
PubMed Central
Keywords
License
Unknown

Abstract

Nanoscale metal-organic frameworks (MOFs) have been widely used as controlled drug delivery vehicles and cancer therapy agents due to their intrinsic superior properties. Scientists have made remarkable achievements in the field of nanomedicine by using the MOFs and MOF-based multifunctional nanomaterials due to the easy synthesis into nanoscale and functionalization. In this review, we highlight the recent progress of nanoscale MOFs as drug delivery vehicles for cancer theranostics. We divide the discussion into three parts. The first and second parts focus on the drug delivery of unmodified MOF and modified MOFs, respectively, while the third part focuses on porphyrin MOFs as photosensitizers for photodynamic therapy. Finally, we conclude by identifying areas of research that we believe will propel the translation and application of MOFs.

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