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Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis.

Authors
  • de Vasconcelos, Nathalia M1, 2
  • Lamkanfi, Mohamed1, 3
  • 1 Department of Internal Medicine and Pediatrics, Ghent University, B-9000 Ghent, Belgium. , (Belgium)
  • 2 VIB-UGhent Center for Inflammation Research, VIB, B-9052 Ghent, Belgium. , (Belgium)
  • 3 Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, B-2340 Beerse, Belgium. , (Belgium)
Type
Published Article
Journal
Cold Spring Harbor Perspectives in Biology
Publisher
Cold Spring Harbor Laboratory
Publication Date
May 01, 2020
Volume
12
Issue
5
Identifiers
DOI: 10.1101/cshperspect.a036392
PMID: 31570336
Source
Medline
Language
English
License
Unknown

Abstract

Inflammasomes assemble in the cytosol of myeloid and epithelial cells on sensing of cellular stress and pathogen-associated molecular patterns and serve as scaffolds for recruitment and activation of inflammatory caspases. Inflammasomes play beneficial roles in host and immune responses against diverse pathogens but may also promote inflammatory tissue damage if uncontrolled. Gasdermin D (GSDMD) is a recently identified substrate of murine caspase-1 and caspase-11, and human caspases-1, -4, and -5 that mediates a regulated lytic cell death mode termed pyroptosis. Recent studies have identified pyroptosis as a critical inflammasome effector mechanism that controls inflammasome-dependent cytokine secretion and contributes to antimicrobial defense and inflammasome-mediated autoinflammatory diseases. Here, we review recent developments on inflammasome-associated effector functions with an emphasis on the emerging roles of gasdermin pores and pyroptosis. Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.

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