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Recent insight into the correlation of SREBP-mediated lipid metabolism and innate immune response

Authors
  • Park, Hyeon Young1
  • Kang, Hye Suk1
  • Im, Seung-Soon1
  • 1 Department of Physiology, Keimyung University School of Medicine, Daegu, South Korea , (North Korea)
Type
Published Article
Journal
Journal of Molecular Endocrinology
Publisher
Bioscientifica
Publication Date
Oct 01, 2018
Volume
61
Issue
3
Identifiers
DOI: 10.1530/JME-17-0289
PMID: 30307160
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Fatty acids are essential nutrients that contribute to several intracellular functions. Fatty acid synthesis and oxidation are known to be regulated by sterol regulatory element-binding proteins (SREBPs), which play a pivotal role in the regulation of cellular triglyceride synthesis and cholesterol biogenesis. Recent studies point to a multifunctional role of SREBPs in the pathogenesis of metabolic diseases, such as obesity, type II diabetes and cancer as well as in immune responses. Notably, fatty acid metabolic intermediates are involved in energy homeostasis and pathophysiological conditions. In particular, intracellular fatty acid metabolism affects an inflammatory response, thereby influencing metabolic diseases. The objective of this review is to summarize the recent advances in our understanding of the dual role of SREBPs in both lipid metabolism and inflammation-mediated metabolic diseases. © 2018 Society for Endocrinology

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