Affordable Access

Publisher Website

Recent Evidence Regarding the Association Between Migraine and Suicidal Behaviors: A Systematic Review

  • Karimi, Leila1, 2
  • Hoppe, Dimi1
  • Burdick, Christine3
  • Buultjens, Melissa1
  • Wijeratne, Tissa1, 4, 5
  • Crewther, Sheila G.1
  • 1 School of Psychology and Public Health, La Trobe University, Melbourne, VIC , (Australia)
  • 2 Faculty of Social and Political Sciences, Ivane Javakhishvili Tbilisi State University, Tbilisi , (Georgia)
  • 3 St. Vincent's Hospital Melbourne, Fitzroy, VIC , (Australia)
  • 4 Department of Neurology, Western Health, AIMSS, Level Three, WHCRE, Sunshine Hospital, University Melbourne, St. Albans, VIC , (Australia)
  • 5 Department of Medicine, Faculty of Medicine, University of Rajarata, Anuradhapura , (Sri Lanka)
Published Article
Frontiers in Neurology
Frontiers Media SA
Publication Date
Jun 23, 2020
DOI: 10.3389/fneur.2020.00490
PMID: 32655476
PMCID: PMC7324711
PubMed Central


Objective: The review presents a systematic analysis of literature investigating the association between migraine and suicidal behaviors. Introduction: Migraine is a common neurological disorder. The prevalence of migraines increases with age from adolescence to adulthood in both sexes, and results in a substantial loss of productivity due to missing days of school or work and need for bed rest. Literature prior to 2015 suggests that migraine is a predictor of suicide. Given the worldwide public health interest in suicide prevention, we examined the literature collected from diverse, predominantly non-European, populations post-2015. Methods: The databases used in this systematic review included: Medline, PsycINFO, EMBASE (Ovid), Science Direct (Elsevier), Cochrane, and PubMed for all available years of publication from January 2015 onwards. The review included participants aged 16 and over who had been diagnosed with migraines with the following outcome variables: any suicidality, both fatal and non-fatal; suicidal ideation; and suicidal behavior. Results: The database searches yielded a total of 542 citations. Following title and abstract screening, 460 articles were excluded and a total of 21 citations were evaluated. After full-text review and excluding a further 11 non-eligible studies, a total of 10 studies were eligible for inclusion in the systematic review. Conclusions: Current existing research highlights the important association between the increased risk of suicidal behaviors in the clinical and general population among chronic migraineurs with/without aura worldwide. Future studies are needed to facilitate the development of clinical guidelines for risk assessment, targeted interventions, and evidence-based treatment of migraine to reduce the risk of suicide among this vulnerable population.

Report this publication


Seen <100 times