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Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases

Authors
  • Zielonka, Jacek
  • Hardy, Micael
  • Michalski, Radoslaw
  • Sikora, Adam
  • Zielonka, Monika
  • Cheng, Gang
  • Ouari, Olivier
  • Podsiadly, Radoslaw
  • Kalyanaraman, Balaraman
Publication Date
Dec 01, 2017
Source
HAL-UPMC
Keywords
Language
English
License
Unknown
External links

Abstract

NADPH oxidases are a family of enzymes capable of transferring electrons from NADPH to molecular oxygen. A major function of NADPH oxidases is the activation of molecular oxygen into reactive oxygen species. Increased activity of NADPH oxidases has been implicated in various pathologies, including cardiovascular disease, neurological dysfunction, and cancer. Thus, NADPH oxidases have been identified as a viable target for the development of novel therapeutics exhibiting inhibitory effects on NADPH oxidases. Here, we describe the development of new assays for measuring the activity of NADPH oxidases enabling the high-throughput screening for NADPH oxidase inhibitors.

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