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Recent developments in PARP14 research.

Authors
  • Tauber, Amanda L1
  • Levonis, Stephan M1
  • Schweiker, Stephanie S1
  • 1 Faculty of Health Sciences & Medicine, Bond University, Gold Coast 4229, Queensland, Australia. , (Australia)
Type
Published Article
Journal
Future Medicinal Chemistry
Publisher
"Future Science, LTD"
Publication Date
Sep 01, 2020
Volume
12
Issue
18
Pages
1657–1667
Identifiers
DOI: 10.4155/fmc-2020-0166
PMID: 32893678
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This review aims to reflect upon the major developments in PARP14 research from late 2017 to early 2020. In doing so, this report will focus on the continual elucidation of PARP14's function including an emerging role in viral replication. This is in addition to other functional developments in cancer and inflammation, along with reflecting upon the leads in inhibitor design, including the increased attention toward the macrodomain. This report will also include a brief recap on contemporary poly(ADP-ribose) polymerase inhibitors and reflect upon the development surrounding the other poly(ADP-ribose) polymerases to overall give a succinct update to assist the development of selective PARP14 inhibitors.

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