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Recent advances in topical nano drug-delivery systems for the anterior ocular segment.

Authors
  • Lakhani, Prit1, 2
  • Patil, Akash1, 2
  • Majumdar, Soumyajit1, 2
  • 1 Department of Pharmaceutics & Drug Delivery, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
  • 2 Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Type
Published Article
Journal
Therapeutic Delivery
Publisher
"Future Science, LTD"
Publication Date
Feb 01, 2018
Volume
9
Issue
2
Pages
137–153
Identifiers
DOI: 10.4155/tde-2017-0088
PMID: 29325511
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Over the past decade, there has been a rise in the number of clinical cases of moderate to severe anterior segment ocular diseases. Conventional topical ophthalmic formulations have several limitations - to address which, novel drug-delivery systems are needed. Additionally, formidable physiological barriers limit ocular bioavailability through the topical route of application. During the last decade, various nano-scaled ocular drug-delivery strategies have been reported. Some of these exploratory, topical, noninvasive approaches have shown promise in improving penetration into the anterior segment tissues of the eye. In this article, we review the available literature with respect to the safety, efficiency and effectiveness of these nano systems.

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