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Recent Advances in the Study of hsp90 Structure and Mechanism of Action.

Authors
  • Toft, D O
Type
Published Article
Journal
Trends in Endocrinology and Metabolism
Publisher
Elsevier
Publication Date
Aug 01, 1998
Volume
9
Issue
6
Pages
238–243
Identifiers
PMID: 18406275
Source
Medline
License
Unknown

Abstract

The 90kDa heat shock protein, hsp90, is a major molecular chaperone of the cell that appears to have particular significance to cellular regulatory processes. New tools and approaches have revealed a number of target proteins for hsp90, most of which are protein kinases or transcription factors. While the mechanism of action of hsp90 is not well understood, reasonable models have emerged describing some functional domains of this protein, the importance of conformational transitions for its activity and its role within a multi-component chaperoning pathway of the cell.

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