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Recent advances in pharmaceutical chemistry--review II. Histamine H2-receptor antagonists.

Authors
  • Lee, R M
  • McDowall, R D
Type
Published Article
Journal
Journal of clinical and hospital pharmacy
Publication Date
Dec 01, 1986
Volume
11
Issue
6
Pages
389–408
Identifiers
PMID: 2880871
Source
Medline
License
Unknown

Abstract

The concept of histamine receptors is outlined and the rationale for the synthesis of H2-antagonists presented. Structure-activity relationships among these compounds are described and aspects of absorption, distribution and elimination discussed with particular reference to cimetidine and ranitidine. Oxmetidine, lupitidine and loxtidine are also considered. Methods for the analysis of these drugs in body fluids are presented followed by a discussion of their toxicology. Volunteer and patient studies are also surveyed.

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