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Recent advances in nanomedicine for sepsis treatment

Authors
  • Yuk, Simseok A1, 1
  • Sanchez-Rodriguez, Diego A2, 2
  • Tsifansky, Michael D3, 3
  • Yeo, Yoon1, 4, 1, 4
  • 1 Department of Industrial & Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
  • 2 Department of Chemical Engineering, National University of Colombia, Bogota 111321, Colombia
  • 3 Department of Pediatrics & the Congenital Heart Center, College of Medicine, University of Florida, Gainesville, FL 32610, USA
  • 4 Weldon School of Biomedical Engineering, Purdue University, 206 South Martin Jischke Drive, West Lafayette, IN 47907, USA
Type
Published Article
Journal
Therapeutic Delivery
Publisher
"Future Science, LTD"
Publication Date
May 03, 2018
Volume
9
Issue
6
Pages
435–450
Identifiers
DOI: 10.4155/tde-2018-0009
PMID: 29722636
PMCID: PMC5994832
Source
PubMed Central
Keywords
License
Unknown

Abstract

Sepsis and septic shock are life-threating conditions, which form a continuum of the body's response to overwhelming infection. The current treatment consists of fluid and metabolic resuscitation, hemodynamic and end-organ support, and timely initiation of antibiotics. However, these measures may be ineffective and the sepsis-related mortality toll remains substantial; therefore, an urgent need exists for new therapies. Recently, several nanoparticle (NP) systems have shown excellent protective effects against sepsis in preclinical models, suggesting a potential utility in the management of sepsis and septic shock. These NPs serve as antibacterial agents, provide platforms to immobilize endotoxin adsorbents, interact with inflammatory cells to restore homeostasis and detect biomarkers of sepsis for timely diagnosis. This review discusses the recent developments in NP-based approaches for the treatment of sepsis.

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