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[Recent advances in molecular mechanisms of supernumerary tooth formation].

Authors
Type
Published Article
Journal
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Publication Date
Volume
45
Issue
4
Pages
661–665
Identifiers
PMID: 23939184
Source
Medline

Abstract

Despite advances in the knowledge of tooth morphogenesis and differentiation, little is relatively known about the aetiology and molecular mechanisms underlying supernumerary tooth formation. Mice, which are commonly used for studying tooth development, only exhibit one dentition. However, a number of mouse models are now starting to provide some insight into the mechanisms that control overall tooth number within the dentition. This review describes recent advances in our understanding of the molecular mechanisms of supernumerary tooth formation. Indeed, many of the molecular signaling pathways known to be involved in normal development of the tooth germ can also give rise to supernumerary teeth if inappropriately regulated. These include components of the Hedgehog, FGF, Wnt and BMP families, which may potentially play a role in human supernumerary tooth formation.

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