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Recent advances in functional assays of transcriptional enhancers.

Authors
  • Babbitt, Courtney C1
  • Markstein, Michele2
  • Gray, Jesse M3
  • 1 Department of Biology, University of Massachusetts, Amherst, United States. Electronic address: [email protected] , (United States)
  • 2 Department of Biology, University of Massachusetts, Amherst, United States. , (United States)
  • 3 Department of Genetics, Harvard Medical School, United States. , (United States)
Type
Published Article
Journal
Genomics
Publisher
Elsevier
Publication Date
Sep 01, 2015
Volume
106
Issue
3
Pages
137–139
Identifiers
DOI: 10.1016/j.ygeno.2015.06.002
PMID: 26100358
Source
Medline
Keywords
License
Unknown

Abstract

In this special edition of Genomics, we present reviews of the current state of the field in identifying and functionally understanding transcriptional enhancers in cells and developing tissues. Typically several enhancers coordinate the expression of an individual target gene, each controlling that gene's expression in specific cell types at specific times. Until recently, identifying each gene's enhancers had been challenging because enhancers do not occupy prescribed locations relative to their target genes. Recently there have been powerful advances in DNA sequencing and other technologies that make it possible to identify the majority of enhancers in virtually any cell type of interest. The reviews in this edition of Genomics highlight some of these new and powerful approaches.

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