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Recent advancement in the mechanism of basophil activation.

Authors
  • Nakashima, Chisa1
  • Otsuka, Atsushi2
  • Kabashima, Kenji3
  • 1 Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan. , (Japan)
  • 2 Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Translational Research Department for Skin and Brain Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address: [email protected] , (Japan)
  • 3 Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore. Electronic address: [email protected] , (Japan)
Type
Published Article
Journal
Journal of dermatological science
Publication Date
Jul 01, 2018
Volume
91
Issue
1
Pages
3–8
Identifiers
DOI: 10.1016/j.jdermsci.2018.03.007
PMID: 29602578
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Basophils have been recognized as crucial players in allergic inflammation. Basophils have the potential to initiate and expand inflammation through the production of specific cytokines and proteases, and are associated with T helper 2 (Th2) immune responses. In addition, recent studies revealed the heterogeneity in basophil populations. Basophils have been clarified important roles in not only IgE-mediated allergic inflammation but also TSLP-mediated and IgE-independent inflammation. Moreover, basophils infiltrate in many human cutaneous diseases. Basophils are responsible for recruiting other inflammatory cells such as macrophages, eosinophils, and fibroblasts. In this review, we discuss recent advances in our understanding of basophil activation and migration in allergic inflammation. Copyright © 2018 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.

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