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RecBC promoted repair of bleomycin damage in Escherichia coli.

Authors
Type
Published Article
Journal
Biochimie
0300-9084
Publisher
Elsevier
Publication Date
Volume
73
Issue
4
Pages
497–500
Identifiers
PMID: 1716995
Source
Medline
License
Unknown

Abstract

The repair response of Escherichia coli K-12 to bleomycin was examined in Rec- mutants showing differential sensitivity to this agent. Sedimentation analysis of the cellular DNA showed incision after bleomycin treatment. The subsequent reformation of the DNA, found in the wild-type and the recD mutant, was abolished in the recB and delayed in the recF and recBC sbcB mutants. The bleomycin-induced SOS response was reduced in strains containing recB or recBC sbsB mutations. It is suggested that the RecBCD pathway has the main role in the efficient repair of bleomycin-induced DNA damage.

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