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Reassortments among avian influenza A(H5N1) viruses circulating in Indonesia, 2015-2016

  • Karo-Karo, Desniwaty
  • Bodewes, Rogier
  • Wibawa, Hendra
  • Artika, I.M.
  • Pribadi, Eko Sugeng
  • Diyantoro, D.
  • Pratomo, Widya
  • Sugama, Agus
  • Hendrayani, Nani
  • Indasari, Iin
  • Wibowo, Michael Haryadi
  • Muljono, David Handojo
  • Stegeman, Jan Arend
  • Koch, Guus
Publication Date
Jan 01, 2019
Wageningen University and Researchcenter Publications
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<p>Highly pathogenic avian influenza (HPAI) A(H5N1) viruses have been circulating since 2003 in Indonesia, with major impacts on poultry health, severe economic losses, and 168 fatal laboratory-confirmed human cases. We performed phylogenetic analysis on 39 full-genome H5N1 virus samples collected during outbreaks among poultry in 2015-2016 in West Java and compared them with recently published sequences from Indonesia. Phylogenetic analysis revealed that the hemagglutinin gene of all samples belonged to 2 genetic groups in clade We also observed these groups for the neuraminidase, nucleoprotein, polymerase, and polymerase basic 1 genes. Matrix, nonstructural protein, and polymerase basic 2 genes of some HPAI were most closely related to clade 2.1.3 instead of clade, and a polymerase basic 2 gene was most closely related to Eurasian low pathogenicity avian influenza. Our results detected a total of 13 reassortment types among HPAI in Indonesia, mostly in backyard chickens in Indramayu.</p>

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