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Rearrangements of the Pim-1, c-myc, and p53 genes in Friend helper virus-induced mouse erythroleukemias.

Authors
  • Dreyfus, F
  • Sola, B
  • Fichelson, S
  • Varlet, P
  • Charon, M
  • Tambourin, P
  • Wendling, F
  • Gisselbrecht, S
Type
Published Article
Journal
Leukemia
Publication Date
Aug 01, 1990
Volume
4
Issue
8
Pages
590–594
Identifiers
PMID: 2143796
Source
Medline
License
Unknown

Abstract

The Friend helper leukemia virus (F-MuLV) induces in mice leukemias of the erythroid, lymphoid, and myeloblastic lineages. Erythroleukemic cell DNAs were examined for genetic alterations at loci described as common proviral integration regions in MuLV-induced myeloid or lymphoid leukemias or in Friend complex-induced erythroleukemias. No alteration of the Fim-1, Fim-2, Fim-3, pvt-1, and Spi-1 loci were detected in 17 erythroleukemias, p53 gene rearrangement was observed in 6 (30%) erythroleukemias and was always associated with a loss of the germ line allele. Interestingly, genetic alterations were also detected at two loci, c-myc and Pim-1, previously described as common provirus integration regions in T lymphoid leukemias. Rearrangements of these two genes were often associated with p53 gene alteration within the same tumor.

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