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Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster.

Authors
  • Ferradini, L
  • Gu, H
  • De Smet, A
  • Rajewsky, K
  • Reynaud, C A
  • Weill, J C
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Mar 08, 1996
Volume
271
Issue
5254
Pages
1416–1420
Identifiers
PMID: 8596914
Source
Medline
License
Unknown

Abstract

Transcriptional regulatory elements have been shown to be necessary but not sufficient for the developmental regulation of immunoglobulin gene rearrangement in mouse precursor B cells. In the chicken lambda light chain locus, additional elements in the V-J intervening sequence are involved in negative and positive regulation of rearrangement. Here, mutation of the mouse homolog of a chicken element, located in the V(K)-J(K) intervening sequence upstream of the J(K) cluster, was shown to significantly decrease rearrangement. This cis-acting recombination-enhancing element affects the rearrangement process without being involved in regulating transcription.

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