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Rearranged patterns of IgH and TcR gamma genes in patients with acute lymphoblastic leukemia.

Authors
  • Li, S
  • Wang, B
  • Li, C
Type
Published Article
Journal
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao
Publication Date
Jan 01, 1997
Volume
17
Issue
4
Pages
206–208
Identifiers
PMID: 9812780
Source
Medline
License
Unknown

Abstract

The rearrangement of immunoglobulin heavy chain gene (IgH) and T cell receptor gamma gene (TcR gamma) was studied in 30 patients with acute lymphoblastic leukemia (ALL) by the polymerase chain reaction (PCR). 19 cases was found to have rearrangement of IgH gene, 12 of TcR gamma. Most of IgH rearrangement was characterized by one or two specific bands while some had more than two. Rearrangement of TcR gamma gene appeared as one specific band. A slight difference in number, size and lightness of bands was found among the patients. 4 different kinds of rearrangement were observed in the detection of IgH rearrangement in combination with TcR gamma gene. The rearranged patterns of IgH and TcR gamma gene as well as the clinical significance were discussed.

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