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Real-time Detection of Air-borne Viruses on a Mass-sensitive Device

Authors
Type
Published Article
Journal
Applied Physics Letters
Publisher
American Institute of Physics
Publication Date
Jul 16, 2008
Volume
93
Issue
1
Identifiers
DOI: 10.1063/1.2956679
PMID: 19529841
PMCID: PMC2682748
Source
LIBNA
License
Green

Abstract

We present real-time detection of airborne Vaccinia viruses using quartz crystal microbalance (QCM) in an integrated manner. Vaccinia viruses were aerosolized and neutralized using an electrospray aerosol generator, transported into the QCM chamber, and captured by a QCM crystal. The capture of the viruses on the QCM crystal resulted in frequency shifts proportional to the number of viruses. The capture rate varied linearly with the concentration of initial virus suspensions (8.5×108–8.5×1010 particles∕ml) at flow rates of 2.0 and 1.1 l∕min. This work demonstrates the general potential of mass sensitive detection of nanoscale biological entities in air.

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