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The reactivity of radiomimetic compounds II

Authors
  • Alexander, P.
  • Cousens, Sheila F.
Type
Published Article
Journal
Biochemical Pharmacology
Publisher
Elsevier
Publication Date
Jan 01, 1958
Volume
1
Issue
1
Pages
25–38
Identifiers
DOI: 10.1016/0006-2952(58)90005-4
Source
Elsevier
License
Unknown

Abstract

Bovine serum albumin has been treated with the following biologically active (radiomimetic) alkylating agents; nitrogen mustards, epoxides, esters of methane sulphonic acid and an ethyleneimine. The extent of reaction with the different reactive side chains of the protein has been determined; all the agents esterify carboxyl groups and react with histidine although in every case only a fraction were accessible to the reagent. Combination with amino groups was only appreciable with the epoxides and none of the reagents reacted with tyrosine. The most reactive groups towards all the alkylating agents were the —SH groups in denatured egg albumin. In the native protein these were not available for reaction.

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