Affordable Access

Reactive astrocyte nomenclature, definitions, and future directions.

Authors
  • Escartin, Carole
  • Galea, Elena
  • Lakatos, András
  • O'Callaghan, James P
  • Petzold, Gabor C
  • Serrano-Pozo, Alberto
  • Steinhäuser, Christian
  • Volterra, Andrea
  • Carmignoto, Giorgio
  • Agarwal, Amit
  • Allen, Nicola J
  • Araque, Alfonso
  • Barbeito, Luis
  • Barzilai, Ari
  • Bergles, Dwight E
  • Bonvento, Gilles
  • Butt, Arthur M
  • Chen, Wei-Ting
  • Cohen-Salmon, Martine
  • Cunningham, Colm
  • And 61 more
Publication Date
Mar 01, 2021
Source
eScholarship - University of California
Keywords
License
Unknown
External links

Abstract

Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.

Report this publication

Statistics

Seen <100 times