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[Reactions to and immunogenic properties of the combined vaccine Bubo-M for immunization of children against diphtheria, tetanus and viral hepatitis B].

Authors
  • Fel'dblium, I V
  • Vorob'eva, N N
  • Nikolaeva, A M
  • Borisova, V N
  • Mel'nikov, V A
  • Budanov, M V
  • Iakovleva, I A
  • Kaz'ianin, A V
  • Pushkareva, E V
  • Griaznov, V N
  • Griaznova, D V
  • Shalunova, N V
  • Perelygina, O V
  • Ozeretskovskiĭ, N A
  • Bektimirov, T A
Type
Published Article
Journal
Zhurnal mikrobiologii, epidemiologii, i immunobiologii
Publication Date
Jan 01, 2001
Issue
6
Pages
50–52
Identifiers
PMID: 11881496
Source
Medline
License
Unknown

Abstract

Bubo-M, the first Russian combined vaccine, was found to have low reactogenicity. The difference between the number of postvaccinal reactions in the group of children immunized with Bubo-M (25.9%) and those in the group of children who had been simultaneously injected into different sites of the body with ADS-M toxoid (adsorbed DT toxoid with reduced antigen content) and hepatitis B vaccine (26.7%) was not statistically significant. Following immunization a considerable increase in the level of diphtheria and tetanus antibodies (p < 0.005) was observed in all children (100%), the level of HBs antibodies in the group of children immunized with Bubo-M (the geometric mean titer: 13,721 IU/l) essentially exceeding that observed in the control group injected with ADS-M toxoid and hepatitis B vaccine (the geometric mean of the titer: 2,441 IU/l). Bubo-M was duly registered and allowed for industrial production and medical use.

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