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Re-examination of chimp protein kinases suggests "novel architectures" are gene prediction artifacts

Authors
  • Robison, Keith1, 2
  • 1 Omics! Omics!, 73 Tewksbury St, Andover, MA, 01810, USA , Andover (United States)
  • 2 Infinity Pharmaceuticals Inc, 780 Memorial Drive, Cambridge, MA, 02139, USA , Cambridge (United States)
Type
Published Article
Journal
BMC Genomics
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 27, 2010
Volume
11
Issue
1
Identifiers
DOI: 10.1186/1471-2164-11-66
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundAnamika et al[1] recently published in this journal a sequence alignment analysis of protein kinases encoded by the chimpanzee genome in comparison to those in the human genome. From this analysis they concluded that several chimpanzee kinases have unusual domain arrangements.ResultsRe-examination of these kinases reveals claimed novel arrangements cannot withstand scrutiny; each is either not novel or represents over-analysis of weakly confident computer generated gene models. Additional sequence evidence available at the time of the paper's submission either directly contradict the gene models or suggest alternate gene models. These alternate models would minimize or eliminate the observed differences between human and chimp kinases.ConclusionNone of the proposed novel chimpanzee kinase architectures are supported by experiment evidence. Guidelines to prevent such erroneous conclusions in similar papers are proposed.

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