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Is There a Rationale for Using Bacillus Calmette-Guerin Vaccine in Coronavirus Infection?

Authors
  • Maheshwari, Nidhi1
  • Jain, Ayush1
  • 1 Department of Pharmacology, Maulana Azad Medical College, New Delhi, India. , (India)
Type
Published Article
Journal
Viral Immunology
Publisher
Mary Ann Liebert
Publication Date
Jun 01, 2021
Volume
34
Issue
5
Pages
300–306
Identifiers
DOI: 10.1089/vim.2020.0079
PMID: 32857679
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Coronavirus disease 2019 (COVID-19) has become a global pandemic in 2020. The pathogen responsible for the COVID-19 has been found to be coronavirus (2019-nCoV) with human transmission through droplets, airway secretions, and even direct contact with host. Currently multiple drugs and their combinations are being tried for the treatment of the COVID-19 disease, but none approved. In absence of definitive and approved treatment, it is imperative that prevention of COVID-19 infection is of utmost importance. For the same, face masks, hand hygiene, isolation, and quarantine are being practiced all over the world. However much successful these methods be, they cannot be used for a very long time. Thus, it becomes necessary that a vaccine be developed for the disease so that the further spread could be halted. Some reports suggest the use of Bacillus Calmette-Guerin (BCG) vaccine as the prophylaxis for coronavirus. BCG vaccine is a live attenuated vaccine, used for prophylaxis of Mycobacterium tuberculosis and is present in the essential list of the World Health Organization as well as immunization programs of many countries. Immunostimulatory antiviral effects of BCG vaccine are well known. At present, there are no published evidence available to support the use of BCG vaccine for the prevention of coronavirus infection. However, there have been speculations on enhanced immunity with BCG vaccine, which might be useful in prevention of coronavirus infection. Results from the clinical studies of BCG vaccine in vulnerable population are required to confirm this hypothesis.

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