A rational free energy-based approach to understanding and targeting disease-causing missense mutations.
Molécules Thérapeutiques In Silico, Inserm UMR-S 973, Université Paris Diderot, Sorbonne Paris Cité, Paris, France
Computational Biophysics and Bioinformatics, Department of Physics, Clemson University, Clemson, South Carolina, USA
Faculty of Pharmaceutical Sciences, Josai University, Tokyo, Japan
- Published Article
Journal of the American Medical Informatics Association
Oxford University Press
- Publication Date
Jun 15, 2013
USPC - SET - SVS
This observation is used to demonstrate, computationally and experimentally, that a particular condition, Snyder-Robinson syndrome caused by the G56S spermine synthase mutation, might be ameliorated by small molecule binding.
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This record was last updated on 03/16/2020 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/23408511