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Rational Design and Synthesis of Post-Functionalizable Peptide Foldamers as Helical Templates.

Authors
  • Misawa, Takashi1
  • Kanda, Yasunari1
  • Demizu, Yosuke1
  • 1 Division of Organic Chemistry and ‡Division of Pharmacology, National Institute of Health Sciences , Tokyo 158-8501, Japan. , (Japan)
Type
Published Article
Journal
Bioconjugate Chemistry
Publisher
American Chemical Society
Publication Date
Dec 20, 2017
Volume
28
Issue
12
Pages
3029–3035
Identifiers
DOI: 10.1021/acs.bioconjchem.7b00621
PMID: 29136364
Source
Medline
License
Unknown

Abstract

In this study, we developed post-functionalizable helical peptides composed of Leu, Aib, and Azl residues. We show that the synthesized peptides 1 and 2 form helical structures, and may be modified using specific side chain or several functional groups by the click reaction without influencing their secondary structures.

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