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Rational design and development of a universal baby spinach-based sensing platform for the detection of biomolecules.

Authors
  • Ji, Danyang1
  • Li, Zhaohui
  • Kwok, Chun Kit
  • 1 Department of Chemistry, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China. [email protected] , (China)
Type
Published Article
Journal
The Analyst
Publisher
The Royal Society of Chemistry
Publication Date
Dec 02, 2019
Volume
144
Issue
24
Pages
7173–7177
Identifiers
DOI: 10.1039/c9an02061f
PMID: 31750452
Source
Medline
Language
English
License
Unknown

Abstract

Here, we designed and developed a Universal Baby Spinach-based Probe (UBSP) for biomolecule detection by introducing a DNA repressor containing a target recognition element. By employing different interaction modes between targets and repressors, we applied the UBSP to detect diverse classes of analytes, including microRNA, proteins, and heavy metal ions.

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