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[Rational concepts and the study of active molecules against various trypanosomiases].

Authors
  • Périé, J
  • de Albuquerque, C
  • Blonski, C
  • Chauvière, G
  • Gefflaut, T
  • Page, P
  • Trinquier, M
  • Willson, M
Type
Published Article
Journal
Bulletin de la Société de pathologie exotique (1990)
Publication Date
Jan 01, 1994
Volume
87
Issue
5
Pages
353–361
Identifiers
PMID: 7496200
Source
Medline
License
Unknown

Abstract

Several sets of compounds, active against different trypanosomes, Trypanosoma brucei and Trypanosoma cruzi are presented, the lethal doses for some of them being less than the micro-molar concentration. These compounds are designed by taking advantage of two metabolic features of these parasites, glucose metabolism and oxidative stress.

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