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RATE OF UTILIZATION OF GLUCOSE AND 'COMPARTMENTATION' OF ALPHA-OXOGLUTARATE AND GLUTAMATE IN RAT BRAIN.

Authors
  • GAITONDE, M K
Type
Published Article
Journal
The Biochemical journal
Publication Date
Jun 01, 1965
Volume
95
Pages
803–810
Identifiers
PMID: 14342519
Source
Medline
Keywords
License
Unknown

Abstract

1. The rate of incorporation of (14)C into pyruvate, alpha-oxoglutarate, lactate and glucose of rat tissues was measured after the subcutaneous injection of uniformly labelled glucose. 2. In rat brain the specific radioactivities of lactate and glucose were similar to that of alanine. In liver the specific radioactivity of glucose was considerably higher than that of lactate or alanine. 3. The specific radioactivities of alpha-oxo acids of rat brain were lower than those of corresponding amino acids, alanine and glutamate. These findings have been explained in relation to metabolic compartments in vivo. 4. The approximate estimated rate of glucose utilization in rat brain in vivo is 0.96mumole/g. of brain/min.

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