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[A rat model of tongue mucosa squamous cell carcinoma induced by oral administration of 4NQO in drinking water].

Authors
Type
Published Article
Journal
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Publication Date
Volume
34
Issue
6
Pages
354–356
Identifiers
PMID: 11776878
Source
Medline
License
Unknown

Abstract

4NQO reliably produced preneoplastic and neoplastic tongue mucosa lesions, which morphologically and histologically mimic human oral carcinogenesis. The rat tongue, a target organ of 4NQO, is not an immunologically privileged site like the hamster buccal pouch. Thus, the model should be appropriate to study molecular mechanism of neoplastic transformation and to assess new treatment modalities of premalignant and malignant lesions of the human oral cavity.

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