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Rat liver lysosome membranes are enriched in alpha-tocopherol.

Authors
  • Rupar, C A
  • Albo, S
  • Whitehall, J D
Type
Published Article
Journal
Biochemistry and cell biology = Biochimie et biologie cellulaire
Publication Date
Jun 01, 1992
Volume
70
Issue
6
Pages
486–488
Identifiers
PMID: 1449715
Source
Medline
License
Unknown

Abstract

The subcellular distribution of alpha-tocopherol has been studied in rat liver. Lysosomal membranes were found to be considerably enriched in alpha-tocopherol with 6300 pmol/mg membrane protein, whereas mitochondrial membranes and microsomes contained 530 and 200 pmol/mg membrane protein, respectively. The 37-fold higher specific content of alpha-tocopherol in lysosomal membranes relative to homogenate indicates that lysosomes could be a target of cellular pathology in vitamin E deficiency states.

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