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A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke.

Authors
  • Chapman, Katie Z
  • Dale, Verity Q
  • Dénes, Adám
  • Bennett, Gavin
  • Rothwell, Nancy J
  • Allan, Stuart M
  • McColl, Barry W
Type
Published Article
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Publication Date
Nov 01, 2009
Volume
29
Issue
11
Pages
1764–1768
Identifiers
DOI: 10.1038/jcbfm.2009.113
PMID: 19654587
Source
Medline
License
Unknown

Abstract

Increasing evidence suggests that peripheral inflammatory responses to stroke and other brain injuries have an important role in determining neurological outcome. The mediators of this response and the temporal relationships between peripheral and central inflammatory alterations are poorly understood. In this study, we show that experimental stroke in mice induces a peripheral inflammatory response that peaks 4 h after stroke, and precedes the peak in brain inflammation 24 h after stroke. This peripheral response is dominated by the induction of the chemokine CXCL-1 and the proinflammatory cytokine interleukin-6 and could serve as an accessible target for therapy and as a source of biomarkers predictive of prognosis.

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