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Rapid and specific detection of Helicobacter pylori macrolide resistance in gastric tissue by fluorescent in situ hybridisation.

Authors
  • Trebesius, K
  • Panthel, K
  • Strobel, S
  • Vogt, K
  • Faller, G
  • Kirchner, T
  • Kist, M
  • Heesemann, J
  • Haas, R
Type
Published Article
Journal
Gut
Publication Date
May 01, 2000
Volume
46
Issue
5
Pages
608–614
Identifiers
PMID: 10764702
Source
Medline
License
Unknown

Abstract

Whole cell hybridisation of rRNA holds great promise for cultivation independent, reliable, and rapid (three hours) genotypic determination of clarithromycin resistance in H pylori. Compared with PCR techniques it is independent of nucleic acid preparations, not prone to inhibition, and allows semiquantitative visualisation of the bacteria within intact tissue samples.

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